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doi: 10. 3389/fphys. 2014.00400. e, Collection 2014. Intercellular interaction in deadly pleural mesothelioma cancer: homes of tunneling nanotubes,,,,,,,,, Affiliations Expand Affiliations 1 Department of Surgical Treatment, Memorial Sloan-Kettering Cancer Center New York, NY, USA. 2 Department of Hematology, Oncology and Transplant, University of Minnesota Minneapolis, MN, USA; Integrative Biology and Physiology Program, University of Minnesota Minneapolis, Minnesota, U.S.A..

4 Department of Biostatistics and Bioinformatics, Masonic Cancer Center, University of Minnesota Minneapolis, MN, U.S.A.. 5 Department of Pathology, Memorial Sloan-Kettering Cancer Center New York City, NY, U.S.A.. 6 Molecular Cytology, Memorial Sloan-Kettering Cancer Center New York, NY, U.S.A.. 7 Department of Cell Biology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center New York, NY, USA.

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Front Physiol. 2014. Free PMC post Program information Show choices Display options Format Abstract Bar, Med PMID doi: 10. 3389/fphys. 2014.00400. e, Collection 2014.  Solution Can Be Seen Here ,,,,,,,,, Affiliations 1 Department of Surgical Treatment, Memorial Sloan-Kettering Cancer Center New York, NY, U.S.A.. 2 Division of Hematology, Oncology and Hair Transplant, University of Minnesota Minneapolis, MN, U.S.A.; Integrative Biology and Physiology Program, University of Minnesota Minneapolis, Minnesota, USA.

4 Department of Biostatistics and Bioinformatics, Masonic Cancer Center, University of Minnesota Minneapolis, MN, U.S.A.. 5 Department of Pathology, Memorial Sloan-Kettering Cancer Center New York, NY, USA. 6 Molecular Cytology, Memorial Sloan-Kettering Cancer Center New York City, NY, USA. 7 Department of Cell Biology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center New York City, NY, USA.

At the cellular level, cultured mesothelioma cancer cells provide a mesenchymal appearance and a strong capacity for regional cellular invasion. One essential but underexplored area of mesothelioma cancer cell biology is intercellular communication. Our group has previously defined in multiple histological subtypes of mesothelioma cancer an unique cellular protrusion referred to as tunneling nanotubes (Tn, Ts).

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Our prior work confirmed the existence of nanotube structures in tumors resected from clients with human mesothelioma. In our existing study, we measured the number of Tn, Ts/cell among various mesothelioma cancer subtypes and typical mesothelial cells utilizing confocal tiny techniques. We also analyzed modifications in Tn, T length over time in comparison to cell proliferation.